Flames broke out at a home along Old State Road in Elmhurst Township, near Moscow, around 2:30 a.m. on Sunday.
The coroner says Heather Eibach, 48, was taken to the hospital, where she later died.
There is no word yet on the man's condition.
A state police fire marshal has been called in to investigate the cause of the fire, but crews do not believe the cause to be suspicious.
The cause of death in the fire in Scranton has been ruled accidental.