Luzerne County 911 dispatchers said someone called around 10:30 a.m. to report a car fire.
Police said a man and a woman inside an SUV parked in the middle of the road, as well as a Good Samaritan who stopped to help, were rushed to the hospital.
A state police hazardous materials team from Harrisburg was called to help remove the suspected meth from the SUV.
A search warrant identified the people in the Chevy Equinox as Jennifer Arnold and Lee Marshall.
The court document said that Marshall told investigators “I was cooking meth and the container blew up”.
Marshall allegedly told police that he was cooking the powerful, illegal stimulant with lighter fluid and Drain-o.
Marshall and Arnold were taken to Geisinger Wyoming Valley Medical Center near Wilkes-Barre, then to other hospitals for treatment.
Kingston Township Police said the Good Samaritan who stopped to help is from West Pittston, and that he was treated and released from the hospital.
Officers told Newswatch 16 that two paramedics were treated for minor burns from the exposure to the chemicals.
Carverton Road reopened about five hours after the incident.
No charges have been filed after the mobile meth lab explosion in Luzerne County.